Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7693
Authors: | Bicker, Frank Nardi, Leonardo Maier, Jannik Vasic, Verica Schmeisser, Michael J. |
Title: | Criss-crossing autism spectrum disorder and adult neurogenesis |
Online publication date: | 7-Sep-2022 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Autism spectrum disorder (ASD) comprises a group of multifactorial neurodevelopmental disorders primarily characterized by deficits in social interaction and repetitive behavior. Although the onset is typically in early childhood, ASD poses a lifelong challenge for both patients and caretakers. Adult neurogenesis (AN) is the process by which new functional neurons are created from neural stem cells existing in the post-natal brain. The entire event is based on a sequence of cellular processes, such as proliferation, specification of cell fate, maturation, and ultimately, synaptic integration into the existing neural circuits. Hence, AN is implicated in structural and functional brain plasticity throughout life. Accumulating evidence shows that impaired AN may underlie some of the abnormal behavioral phenotypes seen in ASD. In this review, we approach the interconnections between the molecular pathways related to AN and ASD. We also discuss existing therapeutic approaches targeting such pathways both in preclinical and clinical studies. A deeper understanding of how ASD and AN reciprocally affect one another could reveal important converging pathways leading to the emergence of psychiatric disorders. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7693 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC-ND |
Information on rights of use: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Journal: | Journal of neurochemistry 159 3 |
Pages or article number: | 452 478 |
Publisher: | Wiley-Blackwell |
Publisher place: | Oxford |
Issue date: | 2021 |
ISSN: | 1471-4159 |
Publisher DOI: | 10.1111/jnc.15501 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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![]() | crisscrossing_autism_spectrum-20220902163708377.pdf | 1.91 MB | Adobe PDF | View/Open |