Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7687
Authors: Wagner, Felix M.
Schuster, Alexander K.
Munder, Annika
Muehl, Marius
Chronopoulos, Panagiotis
Pfeiffer, Norbert
Hoffmann, Esther M.
Title: Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy
Online publication date: 6-Sep-2022
Year of first publication: 2022
Language: english
Abstract: Purpose To assess surgical success and the post-operative development of intraocular pressure between XEN45® gelstent, Preserflo® MicroShunt and trabeculectomy with mitomycin C. Methods Data from 105 eyes from 105 patients of matched cases with refractory open-angle glaucoma, who underwent surgery between January 2019, and August 2020, were evaluated. Patients underwent either stand-alone XEN gelstent insertion with Mitomycin C, stand-alone Preserflo with Mitomycin C or trabeculectomy with Mitomycin C. The primary outcome was the proportion of complete surgical success at 6 months post-operatively (i.e. intraocular pressure between 5mmHg and 18mmHg, no revision surgery, no loss of light perception and no post-operative pharmaceutical antiglaucomatous treatment). The reduction of intraocular pressure after 6 months, the classes of antiglaucomatous medication used post-operatively, best-corrected visual acuity, spherical refractive errors and astigmatism were assessed as secondary outcomes. Results We included 35 eyes in each group. After 6-month follow-up, complete success was 73.5% [95%-CI: 57.9%–89.2%] in the trabeculectomy group, 51.4% [95%-CI: 34.0%–68.8%] in the XEN group and 74.2% [95%-CI: 57.9%–90.5%] in the Preserflo group (p = 0.08). Regarding secondary outcomes, the reduction of intraocular pressure was 12.1 ± 7.9 mmHg in the trabeculectomy group and was thereby 5.8 [95%-CI: 2.2–9.6] mmHg greater compared with the XEN group (p < 0.001) and 4.8 [95%-CI: 0.9–8.7] mmHg higher than the Preserflo group (p = 0.01). Conclusions No statistically significant differences were found between trabeculectomy, XEN45® gelstent implantation and Preserflo® MicroShunt implantation regarding surgical success after 6 months. Yet reduction in intraocular pressure was significantly higher in the trabeculectomy group. However, all three interventions resulted in sufficiently low post-operative intraocular pressure and may therefore be considered individually for glaucoma treatment.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-7687
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
Information on rights of use: https://creativecommons.org/licenses/by-nc/4.0/
Journal: Acta ophthalmologica
100
5
Pages or article number: e1120
e1126
Publisher: Wiley-Blackwell
Publisher place: Oxford
Issue date: 2022
ISSN: 1755-3768
Publisher DOI: 10.1111/aos.15042
Appears in collections:JGU-Publikationen

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