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Authors: Bent, Rebekka
Moll, Lorna
Grabbe, Stephan
Bros, Matthias
Title: Interleukin-1 beta - a friend or foe in malignancies?
Online publication date: 26-Nov-2018
Year of first publication: 2018
Language: english
Abstract: Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial role in resolving acute inflammations, and by initiating adaptive anti-tumor responses. However, IL-1β generated in the course of chronic inflammation supports tumor development. Furthermore, IL-1β generated within the tumor microenvironment predominantly by tumor-infiltrating macrophages promotes tumor growth and metastasis via different mechanisms. These include the expression of IL-1 targets which promote neoangiogenesis and of soluble mediators in cancer-associated fibroblasts that evoke antiapoptotic signaling in tumor cells. Moreover, IL-1 promotes the propagation of myeloid-derived suppressor cells. Using genetic mouse models as well as agents for pharmacological inhibition of IL-1 signaling therapeutically applied for treatment of IL-1 associated autoimmune diseases indicate that IL-1β is a driver of tumor induction and development.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
URN: urn:nbn:de:hebis:77-publ-586594
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: International journal of molecular sciences
Pages or article number: Art. 2155
Publisher: Molecular Diversity Preservation International
Publisher place: Basel
Issue date: 2018
ISSN: 1422-0067
Publisher URL:
Publisher DOI: 10.3390/ijms19082155
Appears in collections:JGU-Publikationen

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