Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-760
Authors: | Bent, Rebekka Moll, Lorna Grabbe, Stephan Bros, Matthias |
Title: | Interleukin-1 beta - a friend or foe in malignancies? |
Online publication date: | 26-Nov-2018 |
Year of first publication: | 2018 |
Language: | english |
Abstract: | Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial role in resolving acute inflammations, and by initiating adaptive anti-tumor responses. However, IL-1β generated in the course of chronic inflammation supports tumor development. Furthermore, IL-1β generated within the tumor microenvironment predominantly by tumor-infiltrating macrophages promotes tumor growth and metastasis via different mechanisms. These include the expression of IL-1 targets which promote neoangiogenesis and of soluble mediators in cancer-associated fibroblasts that evoke antiapoptotic signaling in tumor cells. Moreover, IL-1 promotes the propagation of myeloid-derived suppressor cells. Using genetic mouse models as well as agents for pharmacological inhibition of IL-1 signaling therapeutically applied for treatment of IL-1 associated autoimmune diseases indicate that IL-1β is a driver of tumor induction and development. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-760 |
URN: | urn:nbn:de:hebis:77-publ-586594 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | International journal of molecular sciences 19 8 |
Pages or article number: | Art. 2155 |
Publisher: | Molecular Diversity Preservation International |
Publisher place: | Basel |
Issue date: | 2018 |
ISSN: | 1422-0067 1661-6596 |
Publisher URL: | http://dx.doi.org/10.3390/ijms19082155 |
Publisher DOI: | 10.3390/ijms19082155 |
Appears in collections: | JGU-Publikationen |