Authors:	Siggelkow, Wulf Boehm, Daniel Gebhard, Susanne Battista, Marco Sicking, Isabel Lebrecht, Antje Solbach, Christine Hellwig, Birte Rahnenfuhrer, Jorg Koelbl, Heinz Gehrmann, Mathias Marchan, Rosemarie Cadenas, Cristina Hengstler, Jan G. Schmidt, Marcus
Title:	Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients
Online publication date:	19-Aug-2022
Year of first publication:	2012
Language:	english
Abstract:	BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen receptor (ER), and HER2 were considered. RESULTS: Patients with higher AURKA expression had a shorter metastasis-free survival (MFS) in the
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7579
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/2.0/
Journal:	BMC cancer 12
Pages or article number:	Art. 562
Publisher:	Springer
Publisher place:	London
Issue date:	2012
ISSN:	1471-2407
Publisher URL:	http://dx.doi.org/10.1186/1471-2407-12-562
Publisher DOI:	10.1186/1471-2407-12-562
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)