Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7579
Authors: | Siggelkow, Wulf Boehm, Daniel Gebhard, Susanne Battista, Marco Sicking, Isabel Lebrecht, Antje Solbach, Christine Hellwig, Birte Rahnenfuhrer, Jorg Koelbl, Heinz Gehrmann, Mathias Marchan, Rosemarie Cadenas, Cristina Hengstler, Jan G. Schmidt, Marcus |
Title: | Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients |
Online publication date: | 19-Aug-2022 |
Year of first publication: | 2012 |
Language: | english |
Abstract: | BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen receptor (ER), and HER2 were considered. RESULTS: Patients with higher AURKA expression had a shorter metastasis-free survival (MFS) in the |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7579 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/2.0/ |
Journal: | BMC cancer 12 |
Pages or article number: | Art. 562 |
Publisher: | Springer |
Publisher place: | London |
Issue date: | 2012 |
ISSN: | 1471-2407 |
Publisher URL: | http://dx.doi.org/10.1186/1471-2407-12-562 |
Publisher DOI: | 10.1186/1471-2407-12-562 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
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![]() | expression_of_aurora_kinase_a-20220817163552627.pdf | 1.39 MB | Adobe PDF | View/Open |