Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

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dc.contributor.authorSiggelkow, Wulf
dc.contributor.authorBoehm, Daniel
dc.contributor.authorGebhard, Susanne
dc.contributor.authorBattista, Marco
dc.contributor.authorSicking, Isabel
dc.contributor.authorLebrecht, Antje
dc.contributor.authorSolbach, Christine
dc.contributor.authorHellwig, Birte
dc.contributor.authorRahnenfuhrer, Jorg
dc.contributor.authorKoelbl, Heinz
dc.contributor.authorGehrmann, Mathias
dc.contributor.authorMarchan, Rosemarie
dc.contributor.authorCadenas, Cristina
dc.contributor.authorHengstler, Jan G.
dc.contributor.authorSchmidt, Marcus
dc.date.accessioned2022-08-19T10:06:33Z
dc.date.available2022-08-19T10:06:33Z
dc.date.issued2012
dc.description.abstractBACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen receptor (ER), and HER2 were considered. RESULTS: Patients with higher AURKA expression had a shorter metastasis-free survival (MFS) in theen_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.identifier.doihttp://doi.org/10.25358/openscience-7579
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7593
dc.language.isoengde
dc.rightsCC-BY-2.0*
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleExpression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patientsen_GB
dc.typeZeitschriftenaufsatzde
jgu.identifier.pmid23186136
jgu.journal.titleBMC cancerde
jgu.journal.volume12de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternativeArt. 562de
jgu.publisher.doi10.1186/1471-2407-12-562de
jgu.publisher.issn1471-2407de
jgu.publisher.nameSpringerde
jgu.publisher.placeLondonde
jgu.publisher.urihttp://dx.doi.org/10.1186/1471-2407-12-562de
jgu.publisher.year2012
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde
opus.affiliatedBattista, Marco
opus.affiliatedSicking, Isabel
opus.affiliatedLebrecht, Antje
opus.affiliatedSolbach, Christine
opus.affiliatedSchmidt, Marcus
opus.date.modified2015-09-17T09:36:57Z
opus.identifier.opusid23651
opus.importsourcepubmed
opus.institute.number0445
opus.metadataonlyfalse
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Geburtshilfe und Frauenkrankheitende_DE
opus.subject.dfgcode04-205
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN

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