Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7498
Authors: | Krajnak, Slavomir Jäkel, Jörg Anić, Katharina Schwab, Roxana Schmidt, Marcus Hasenburg, Annette Roth, Wilfried Brenner, Walburgis Battista, Marco Johannes |
Title: | Role of integrins in the metastatic spread of high-grade serous ovarian cancer |
Online publication date: | 4-Aug-2022 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Purpose Integrins may be involved in the metastatic spread of high-grade serous ovarian cancer (HGSOC) which determines the therapeutical approach and prognosis. We investigated the integrin expression in primary tumor and metastases of advanced HGSOC. Methods The expression of integrin α2, α4, α5, α6, and β1 was assessed by immunostaining in tumor samples of the ovary, omentum, and peritoneum of each patient. Differences in integrin expression among tumor localizations and their association with clinicopathological parameters were examined by Fisher’s exact test. The impact of integrin expression on progression-free survival (PFS) and overall survival (OS) was examined by Cox regression and Kaplan–Meier analyses. Results Hundred and thirteen tumor samples of 40 HGSOC patients were examined. The expression of the integrins did not differ between the three tumor localizations (all p values > 0.05) with the exception of high expression of integrin α4 in primary tumor and omentum (52.5% versus 47.5%, p = 0.008) and primary tumor and peritoneum (52.5% versus 47.5%, p = 0.050). High expression of integrin α4 in peritoneum was associated with poorer PFS (HR 2.02 95% CI 1.01–4.05, p = 0.047), younger age (p = 0.047), and death (p = 0.046). Median PFS in patients with high expression of integrin α4 was 13.00 months, whereas median PFS in patients without high expression of integrin α4 was 21.00 months (p = 0.040). Expression of other integrins did not correlate with PFS or OS. Conclusion Expression of integrin α4 may be altered during the metastatic spread of HGSOC and affect prognosis, whereas expression of integrin α2, α5, α6, and β1 did not reveal any prognostic value. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7498 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Archives of gynecology and obstetrics 305 |
Pages or article number: | 1291 1298 |
Publisher: | Springer |
Publisher place: | Berlin u.a. |
Issue date: | 2022 |
ISSN: | 1432-0711 |
Publisher DOI: | 10.1007/s00404-021-06281-7 |
Appears in collections: | JGU-Publikationen |
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File | Description | Size | Format | ||
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![]() | role_of_integrins_in_the_meta-20220801120419305.pdf | 1.04 MB | Adobe PDF | View/Open |