Authors:	Korb, Christina Zwiener, Isabella Lorenz, Katrin Mirshahi, Alireza Pfeiffer, Norbert Stoffelns, Bernhard
Title:	Risk factors of a reduced response to ranibizumab treatment for neovascular age-related macular degeneration : evaluation in a clinical setting
Online publication date:	12-Jul-2022
Year of first publication:	2013
Language:	english
Abstract:	BACKGROUND: To identify risk factors for being a "reduced responder" to ranibizumab treatment in a clinical setting in patients with neovascular age-related macular degeneration. METHODS: This retrospective study included 165 eyes of 165 consecutive patients with choroidal neovascularisation secondary to neovascular, age-related macular degeneration. Eyes were treated with three intravitreal injections of ranibizumab, followed by PRN (pro re nata) dosing thereafter. All patients were reevaluated every four weeks and then followed for six months. Reduced responders were defined as patients with a loss in visual acuity of at least 1 visual acuity line at the last follow-up and/or persistent intraretinal or subretinal fluid or detectable choroidal neovascularisation at the last follow-up, compared to baseline. RESULTS: Overall, 58 out of 165 eyes (35.2%) were considered to be reduced responders to treatment at the end of follow-up. The initial CNV size at baseline was correlated with the risk of being a reduced responder at the end of follow-up (p = 0.017). CONCLUSION: We identified the initial lesion size as a predictor for a reduced response to treatment in this study. Patients with a large initial lesion size should be thoroughly informed about the possible poorer response to the intravitreal treatment.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7362
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/2.0/
Journal:	BMC ophthalmology 13
Pages or article number:	Art. 84
Publisher:	BioMed Central
Publisher place:	London
Issue date:	2013
ISSN:	1471-2415
Publisher URL:	http://dx.doi.org/10.1186/1471-2415-13-84
Publisher DOI:	10.1186/1471-2415-13-84
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)