Autoren:	Korb, Christina Zwiener, Isabella Lorenz, Katrin Mirshahi, Alireza Pfeiffer, Norbert Stoffelns, Bernhard
Titel:	Risk factors of a reduced response to ranibizumab treatment for neovascular age-related macular degeneration : evaluation in a clinical setting
Online-Publikationsdatum:	12-Jul-2022
Erscheinungsdatum:	2013
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	BACKGROUND: To identify risk factors for being a "reduced responder" to ranibizumab treatment in a clinical setting in patients with neovascular age-related macular degeneration. METHODS: This retrospective study included 165 eyes of 165 consecutive patients with choroidal neovascularisation secondary to neovascular, age-related macular degeneration. Eyes were treated with three intravitreal injections of ranibizumab, followed by PRN (pro re nata) dosing thereafter. All patients were reevaluated every four weeks and then followed for six months. Reduced responders were defined as patients with a loss in visual acuity of at least 1 visual acuity line at the last follow-up and/or persistent intraretinal or subretinal fluid or detectable choroidal neovascularisation at the last follow-up, compared to baseline. RESULTS: Overall, 58 out of 165 eyes (35.2%) were considered to be reduced responders to treatment at the end of follow-up. The initial CNV size at baseline was correlated with the risk of being a reduced responder at the end of follow-up (p = 0.017). CONCLUSION: We identified the initial lesion size as a predictor for a reduced response to treatment in this study. Patients with a large initial lesion size should be thoroughly informed about the possible poorer response to the intravitreal treatment.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7362
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/2.0/
Zeitschrift:	BMC ophthalmology 13
Seitenzahl oder Artikelnummer:	Art. 84
Verlag:	BioMed Central
Verlagsort:	London
Erscheinungsdatum:	2013
ISSN:	1471-2415
URL der Originalveröffentlichung:	http://dx.doi.org/10.1186/1471-2415-13-84
DOI der Originalveröffentlichung:	10.1186/1471-2415-13-84
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)