Authors:	Wasielica-Poslednik, Joanna Butsch, Christina Lampe, Christina Elflein, Heike Lamparter, Julia Weyer, Veronika Pitz, Susanne
Title:	Comparison of rebound tonometry, Perkins applanation tonometry and ocular response analyser in mucopolysaccharidosis patients
Online publication date:	12-Jul-2022
Year of first publication:	2015
Language:	english
Abstract:	Aims To investigate the feasibility and to compare three devices measuring intraocular pressure (IOP) in mucopolysaccharidosis patients (MPS): iCare rebound tonometer (RT), Perkins applanation tonometer (PAT) and ocular response analyzer (ORA) Methods MPS patients who underwent at least two examinations out of: RT, PAT and ORA at the same visit were identified and retrospectively analyzed in this study. Results 17 patients fulfilled the inclusion criterion. In all 17 patients IOP measurements were performed with RT (34 eyes) and ORA (33 eyes), while PAT measurement was possible in only 12 (24 eyes) patients. The RT, corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg) differed relevantly from IOP assessed with PAT. Corneal clouding in MPS patients correlated positively with PAT, RT and IOPg (r = 0.3, 0.5, and 0.5 respectively), but not with IOPcc (r = 0.07). The MPS-related corneal clouding correlated positively with biomechanical corneal parameters assessed with ORA: corneal hysteresis (r = 0.77) and corneal resistance factor (r = 0.77) either. Conclusions RT and ORA measurements were tolerated better than applanation tonometry in MPS patients. IOP measurements assessed with RT and ORA differed relevantly from PAT. Corneal-compensated IOP assessed with ORA seems to be less affected by the MPS-related corneal clouding than applanation or rebound tonometry. RT and ORA measurements should be preferred for IOP assessment in patients with MPS.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7358
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	PLoS one 10 8
Pages or article number:	e0133586
Publisher:	PLoS
Publisher place:	Lawrence, Kan.
Issue date:	2015
ISSN:	1932-6203
Publisher URL:	http://dx.doi.org/10.1371/journal.pone.0133586
Publisher DOI:	10.1371/journal.pone.0133586
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)