Authors:	Hutten, Saskia Dormann, Dorothee
Title:	Gestörter Kerntransport und Phasentrennung von RNA-Bindeproteinen
Online publication date:	4-Jul-2022
Year of first publication:	2021
Language:	german
Abstract:	Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disordes, whose underlying molecular mechanisms are only beginning to emerge. A common molecular hallmark of both diseases is the relocalization of nuclear RNA-binding proteins (RBP) into cytoplasmic aggregates. Defects in nuclear import and aberrant phase separation appear to underlie RBP mislocalization and aggregation and could potentially be targeted in future therapies.
DDC:	570 Biowissenschaften 570 Life sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 10 Biologie
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7291
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Biospektrum 27
Pages or article number:	365 367
Publisher:	Spektrum
Publisher place:	Heidelberg
Issue date:	2021
ISSN:	1868-6249
Publisher DOI:	10.1007/s12268-021-1599-z
Appears in collections:	JGU-Publikationen