Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7274Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Riegel, Kristina | - |
| dc.contributor.author | Yurugi, Hajime | - |
| dc.contributor.author | Schlöder, Janine | - |
| dc.contributor.author | Jonuleit, Helmut | - |
| dc.contributor.author | Kaulich, Manuel | - |
| dc.contributor.author | Kirschner, Friederike | - |
| dc.contributor.author | Arnold-Schild, Danielle | - |
| dc.contributor.author | Tenzer, Stefan | - |
| dc.contributor.author | Schild, Hansjörg | - |
| dc.contributor.author | Rajalingam, Krishnaraj | - |
| dc.date.accessioned | 2022-07-01T08:58:15Z | - |
| dc.date.available | 2022-07-01T08:58:15Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7288 | - |
| dc.description.abstract | Tumors exhibit a variety of strategies to dampen antitumor immune responses. With an aim to identify factors that are secreted from tumor cells, we performed an unbiased mass spectrometry-based secretome analysis in lung cancer cells. Interleukin-6 (IL-6) has been identified as a prominent factor secreted by tumor cells and cancer-associated fibroblasts isolated from cancer patients. Incubation of dendritic cell (DC) cultures with tumor cell supernatants inhibited the production of IL-12p70 in DCs but not the surface expression of other activation markers which is reversed by treatment with IL-6 antibody. Defects in IL-12p70 production in the DCs inhibited the differentiation of Th1 but not Th2 and Th17 cells from naïve CD4+ T cells. We also demonstrate that the classical mitogen-activated protein kinase, ERK5/MAPK7, is required for IL-6 production in tumor cells. Inhibition of ERK5 activity or depletion of ERK5 prevented IL-6 production in tumor cells, which could be exploited for enhancing antitumor immune responses. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7274 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Cell death & disease | de |
| jgu.journal.volume | 12 | de |
| jgu.pages.alternative | 969 | de |
| jgu.publisher.year | 2021 | - |
| jgu.publisher.name | Nature Publishing Group | de |
| jgu.publisher.place | London u.a. | de |
| jgu.publisher.issn | 2041-4889 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1038/s41419-021-04257-8 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | JGU-Publikationen | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | erk5_modulates_il6_secretion_-20220701105326466.pdf | 1.61 MB | Adobe PDF | View/Open |