Autoren:	Gairing, Simon Johannes Galle, Peter Robert Schattenberg, Jörn Markus Kostev, Karel Labenz, Christian
Titel:	Portal vein thrombosis is associated with an increased risk of bone fractures
Online-Publikationsdatum:	13-Jan-2023
Erscheinungsdatum:	2022
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Background: Portal vein thrombosis (PVT) is a rare but severe disease that often leads to portal hypertension-related complications. It is well-known that patients with portal hypertension associated with liver cirrhosis are at increased risk for bone fractures, however data on the impact of PVT on fracture risk are lacking. Aims: This study aimed to explore the impact of PVT on the incidence of bone fractures in a large German primary care cohort.MethodsPatients with PVT were extensively matched to non-PVT individuals in a 1:5 ratio. The primary outcome of the study was the incidence of any bone fracture. Results: This study included 596 patients with PVT and 2,980 non-PVT individuals. During five years of follow-up, the cumulative incidence of bone fractures was significantly higher in PVT patients (n = 87, 13.6%) than in those without PVT (n = 186, 6.7%) (pConclusionsPVT is independently associated with a higher incidence of bone fractures. Patients with PVT should be critically evaluated for fracture risk and preventive measures should be considered.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7254
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	PLOS ONE 17 4
Seitenzahl oder Artikelnummer:	e0267535
Verlag:	PLOS
Verlagsort:	San Francisco, California, US
Erscheinungsdatum:	2022
ISSN:	1932-6203
DOI der Originalveröffentlichung:	10.1371/journal.pone.0267535
Enthalten in den Sammlungen:	DFG-491381577-G