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Authors: Gairing, Simon Johannes
Galle, Peter Robert
Schattenberg, Jörn Markus
Kostev, Karel
Labenz, Christian
Title: Portal vein thrombosis is associated with an increased risk of bone fractures
Online publication date: 13-Jan-2023
Year of first publication: 2022
Language: english
Abstract: Background: Portal vein thrombosis (PVT) is a rare but severe disease that often leads to portal hypertension-related complications. It is well-known that patients with portal hypertension associated with liver cirrhosis are at increased risk for bone fractures, however data on the impact of PVT on fracture risk are lacking. Aims: This study aimed to explore the impact of PVT on the incidence of bone fractures in a large German primary care cohort.MethodsPatients with PVT were extensively matched to non-PVT individuals in a 1:5 ratio. The primary outcome of the study was the incidence of any bone fracture. Results: This study included 596 patients with PVT and 2,980 non-PVT individuals. During five years of follow-up, the cumulative incidence of bone fractures was significantly higher in PVT patients (n = 87, 13.6%) than in those without PVT (n = 186, 6.7%) (pConclusionsPVT is independently associated with a higher incidence of bone fractures. Patients with PVT should be critically evaluated for fracture risk and preventive measures should be considered.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY
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Journal: PLOS ONE
Pages or article number: e0267535
Publisher: PLOS
Publisher place: San Francisco, California, US
Issue date: 2022
ISSN: 1932-6203
Publisher DOI: 10.1371/journal.pone.0267535
Appears in collections:DFG-491381577-G

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