Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7254
Authors: | Gairing, Simon Johannes Galle, Peter Robert Schattenberg, Jörn Markus Kostev, Karel Labenz, Christian |
Title: | Portal vein thrombosis is associated with an increased risk of bone fractures |
Online publication date: | 13-Jan-2023 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Background: Portal vein thrombosis (PVT) is a rare but severe disease that often leads to portal hypertension-related complications. It is well-known that patients with portal hypertension associated with liver cirrhosis are at increased risk for bone fractures, however data on the impact of PVT on fracture risk are lacking. Aims: This study aimed to explore the impact of PVT on the incidence of bone fractures in a large German primary care cohort.MethodsPatients with PVT were extensively matched to non-PVT individuals in a 1:5 ratio. The primary outcome of the study was the incidence of any bone fracture. Results: This study included 596 patients with PVT and 2,980 non-PVT individuals. During five years of follow-up, the cumulative incidence of bone fractures was significantly higher in PVT patients (n = 87, 13.6%) than in those without PVT (n = 186, 6.7%) (pConclusionsPVT is independently associated with a higher incidence of bone fractures. Patients with PVT should be critically evaluated for fracture risk and preventive measures should be considered. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7254 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Scientific article |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | PLOS ONE 17 4 |
Pages or article number: | e0267535 |
Publisher: | PLOS |
Publisher place: | San Francisco, California, US |
Issue date: | 2022 |
ISSN: | 1932-6203 |
Publisher DOI: | 10.1371/journal.pone.0267535 |
Appears in collections: | DFG-491381577-G |
Files in This Item:
File | Description | Size | Format | ||
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![]() | portal_vein_thrombosis_is_ass-20220628142659913.pdf | 1.05 MB | Adobe PDF | View/Open |