Authors:	Metzig, Marie Oliver Hoffmann, Alexander
Title:	Controlling cancer cell death types to optimize anti-tumor immunity
Online publication date:	13-Jan-2023
Year of first publication:	2022
Language:	english
Abstract:	Over several decades, cell biology research has characterized distinct forms of regulated cell death, identified master regulators such as nuclear factor kappa B (NFκB), and contributed to translating these findings in order to improve anti-cancer therapies. In the era of immunotherapy, however, the field warrants a new appraisal—the targeted induction of immunogenic cell death may offer personalized strategies to optimize anti-tumor immunity. Once again, the spotlight is on NFκB, which is not only a master regulator of cancer cell death, survival, and inflammation, but also of adaptive anti-tumor immune responses that are triggered by dying tumor cells.
DDC:	570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7250
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Biomedicines 10 5
Pages or article number:	974
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2022
ISSN:	2227-9059
Publisher DOI:	10.3390/biomedicines10050974
Appears in collections:	DFG-491381577-G