Gutenberg Open Science: Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7178

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DC Field	Value	Language
dc.contributor.author	Hubo, Mario	-
dc.contributor.author	Trinschek, Bettina	-
dc.contributor.author	Kryczanowsky, Fanny	-
dc.contributor.author	Tüttenberg, Andrea	-
dc.contributor.author	Steinbrink, Kerstin	-
dc.contributor.author	Jonuleit, Helmut	-
dc.date.accessioned	2022-06-20T08:53:12Z	-
dc.date.available	2022-06-20T08:53:12Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7192	-
dc.description.abstract	Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct stages of differentiation, immunogenic versus tolerogenic. Dependent on local micro milieu and inflammatory stimuli, tissue resident immature DC with functional plasticity differentiate into tolerogenic or immunogenic DC with stable phenotypes. They efficiently link innate and adaptive immunity and are ideally positioned to modify T cell-mediated immune responses. Since the T cell stimulatory properties of DC are significantly influenced by their expression of signal II ligands, it is critical to understand the impact of distinct costimulatory pathways on DC function. This review gives an overview of functional different human DC subsets with unique profiles of costimulatory molecules and outlines how different costimulatory pathways together with the immunosuppressive cytokine IL-10 bias immunogenic versus tolerogenic DC functions. Furthermore, we exemplarily describe protocols for the generation of two well-defined monocyte-derived DC subsets for their clinical use, immunogenic versus tolerogenic.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7178	-
jgu.type.contenttype	Review	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Frontiers in immunology	de
jgu.journal.volume	4	de
jgu.pages.alternative	82	de
jgu.publisher.year	2013	-
jgu.publisher.name	Frontiers Media	de
jgu.publisher.place	Lausanne	de
jgu.publisher.uri	http://dx.doi.org/10.3389/fimmu.2013.00082	de
jgu.publisher.issn	1664-3224	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-07-31T09:43:33Z	-
opus.subject.dfgcode	04-204	-
opus.organisation.string	FB 04: Medizin: Hautklinik	de_DE
opus.identifier.opusid	22809	-
opus.institute.number	0431	-
opus.metadataonly	false	-
opus.type.contenttype	Übersichtsartikel	de_DE
opus.type.contenttype	Review Article	en_EN
opus.affiliated	Tüttenberg, Andrea	-
opus.affiliated	Steinbrink, Kerstin	-
opus.affiliated	Jonuleit, Helmut	-
jgu.publisher.doi	10.3389/fimmu.2013.00082	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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