Authors:	Hubo, Mario Trinschek, Bettina Kryczanowsky, Fanny Tüttenberg, Andrea Steinbrink, Kerstin Jonuleit, Helmut
Title:	Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells
Online publication date:	20-Jun-2022
Year of first publication:	2013
Language:	english
Abstract:	Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct stages of differentiation, immunogenic versus tolerogenic. Dependent on local micro milieu and inflammatory stimuli, tissue resident immature DC with functional plasticity differentiate into tolerogenic or immunogenic DC with stable phenotypes. They efficiently link innate and adaptive immunity and are ideally positioned to modify T cell-mediated immune responses. Since the T cell stimulatory properties of DC are significantly influenced by their expression of signal II ligands, it is critical to understand the impact of distinct costimulatory pathways on DC function. This review gives an overview of functional different human DC subsets with unique profiles of costimulatory molecules and outlines how different costimulatory pathways together with the immunosuppressive cytokine IL-10 bias immunogenic versus tolerogenic DC functions. Furthermore, we exemplarily describe protocols for the generation of two well-defined monocyte-derived DC subsets for their clinical use, immunogenic versus tolerogenic.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7178
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Review
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/3.0/
Journal:	Frontiers in immunology 4
Pages or article number:	82
Publisher:	Frontiers Media
Publisher place:	Lausanne
Issue date:	2013
ISSN:	1664-3224
Publisher URL:	http://dx.doi.org/10.3389/fimmu.2013.00082
Publisher DOI:	10.3389/fimmu.2013.00082
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)