Autoren:	Hubo, Mario Trinschek, Bettina Kryczanowsky, Fanny Tüttenberg, Andrea Steinbrink, Kerstin Jonuleit, Helmut
Titel:	Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells
Online-Publikationsdatum:	20-Jun-2022
Erscheinungsdatum:	2013
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct stages of differentiation, immunogenic versus tolerogenic. Dependent on local micro milieu and inflammatory stimuli, tissue resident immature DC with functional plasticity differentiate into tolerogenic or immunogenic DC with stable phenotypes. They efficiently link innate and adaptive immunity and are ideally positioned to modify T cell-mediated immune responses. Since the T cell stimulatory properties of DC are significantly influenced by their expression of signal II ligands, it is critical to understand the impact of distinct costimulatory pathways on DC function. This review gives an overview of functional different human DC subsets with unique profiles of costimulatory molecules and outlines how different costimulatory pathways together with the immunosuppressive cytokine IL-10 bias immunogenic versus tolerogenic DC functions. Furthermore, we exemplarily describe protocols for the generation of two well-defined monocyte-derived DC subsets for their clinical use, immunogenic versus tolerogenic.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7178
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Review
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/3.0/
Zeitschrift:	Frontiers in immunology 4
Seitenzahl oder Artikelnummer:	82
Verlag:	Frontiers Media
Verlagsort:	Lausanne
Erscheinungsdatum:	2013
ISSN:	1664-3224
URL der Originalveröffentlichung:	http://dx.doi.org/10.3389/fimmu.2013.00082
DOI der Originalveröffentlichung:	10.3389/fimmu.2013.00082
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)