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Authors: Xia, Ning
Förstermann, Ulrich
Li, Huige
Title: Resveratrol and endothelial nitric oxide
Online publication date: 14-Jun-2022
Language: english
Abstract: Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Review
License: CC BY
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Journal: Molecules
Pages or article number: 16102
Publisher: MDPI
Publisher place: Basel
Issue date: 2014
ISSN: 1420-3049
Publisher URL:
Publisher DOI: 10.3390/molecules191016102
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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