Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7141
Authors: | Xia, Ning Förstermann, Ulrich Li, Huige |
Title: | Resveratrol and endothelial nitric oxide |
Online publication date: | 14-Jun-2022 |
Year of first publication: | 2014 |
Language: | english |
Abstract: | Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7141 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Review |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Molecules 19 10 |
Pages or article number: | 16102 16121 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2014 |
ISSN: | 1420-3049 |
Publisher URL: | http://dx.doi.org/10.3390/molecules191016102 |
Publisher DOI: | 10.3390/molecules191016102 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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resveratrol_and_endothelial_n-20220614092201451.pdf | 959.49 kB | Adobe PDF | View/Open |