Resveratrol and endothelial nitric oxide

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dc.contributor.authorXia, Ning
dc.contributor.authorFörstermann, Ulrich
dc.contributor.authorLi, Huige
dc.date.accessioned2022-06-14T07:29:40Z
dc.date.available2022-06-14T07:29:40Z
dc.date.issued2014
dc.description.abstractNitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.de_DE
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
dc.identifier.doihttp://doi.org/10.25358/openscience-7141
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7155
dc.language.isoeng
dc.rightsCC-BY-4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleResveratrol and endothelial nitric oxidede_DE
dc.typeZeitschriftenaufsatzde_DE
jgu.apc.price1512,32
jgu.journal.issue10
jgu.journal.titleMolecules
jgu.journal.volume19
jgu.organisation.departmentFB 04 Medizinde_DE
jgu.organisation.nameJohannes Gutenberg-Universität Mainzde_DE
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end16121
jgu.pages.start16102
jgu.publisher.doi10.3390/molecules191016102
jgu.publisher.issn1420-3049
jgu.publisher.nameMDPI
jgu.publisher.placeBasel
jgu.publisher.urihttp://dx.doi.org/10.3390/molecules191016102
jgu.publisher.year2014
jgu.rights.accessrightsopenAccessen_GB
jgu.subject.ddccode610
jgu.type.contenttypeReviewen_GB
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTexten_GB
jgu.type.versionPublished versionen_GB
opus.affiliatedXia, Ning
opus.affiliatedFörstermann, Ulrich
opus.affiliatedLi, Huige
opus.date.modified2018-08-09T08:24:09Z
opus.identifier.opusid27362
opus.institute.number0413
opus.metadataonlyfalse
opus.organisation.stringFB 04: Medizin: Institut für Pharmakologie
opus.subject.dfgcode04-205
opus.type.contenttypeÜbersichtsartikel
opus.type.contenttypeReview Article

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