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Authors: Prochaska, Jürgen H.
Frank, Bernd
Nagler, Markus
Lamparter, Heidrun
Weißer, Gerhard
Schulz, Andreas
Eggebrecht, Lisa
Göbel, Sebastian
Arnold, Natalie
Panova-Noeva, Marina
Hermanns, Iris
Pinto, Antonio
Konstantinides, Stavros
ten Cate, Hugo
Lackner, Karl J.
Münzel, Thomas
Espinola-Klein, Christine
Wild, Philipp
Title: Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis
Online publication date: 13-Jun-2022
Language: english
Abstract: Previous reports have investigated the impact of age on D-Dimer testing in elderly individuals with suspected deep vein thrombosis (DVT), but data on the age-related diagnostic value of D-dimer in a sample covering a broad age range are limited. The present study determined age-specifically the diagnostic accuracy of D-dimer and compared it to C-reactive protein (CRP), a marker of inflammation, in 500 patients with suspected DVT from the VTEval project (NCT02156401). Sensitivity of D-dimer was lower in patients < 60 years in comparison to patients ≥ 60 years (∆−16.8%), whereas specificity was 27.9% higher. Lowest levels of sensitivity were detected for female sex, unprovoked DVT, low thrombotic burden, and distal DVT. A fixed D-dimer threshold of 0.25 mg/L FEU resulted in elevated sensitivity for patients < 60 with a reduction of false negatives by 40.0% for proximal DVT and by 50.0% for distal DVT. In patients < 60 years, D-dimer and CRP demonstrated comparable diagnostic performance for both proximal and distal DVT (p > 0.05). In conclusion, these data outline a clinically-relevant limitation of D-dimer testing among younger patients with suspected DVT indicating a necessity for age-adapted cut-off values. Further research is required to decrypt the role of inflammation in the pathophysiology and diagnosis of venous thrombosis.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use:
Journal: Scientific reports
Pages or article number: Art. 4591
Publisher: Macmillan Publishers Limited, part of Springer Nature
Publisher place: London
Issue date: 2017
ISSN: 2045-2322
Publisher URL:
Publisher DOI: 10.1038/s41598-017-04843-x
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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