A copper-catalyzed synthesis of pyrroles through photochemically generated acylazirines
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Abstract
A synthesis of highly substituted 2,4-diacylpyrroles through a Cu-catalyzed dimerization of acylazirines generated in situ by a photochemical valence isomerization is described. The shown methodology allows the use of simple precursors and a readily available copper(II)-catalyst. Since the reaction is best performed at elevated temperatures, a method to adjust the temperature of the reaction mixture during this dual light and metal-induced process was established. Additionally, mechanistic studies of the reaction were performed in order to provide a deeper understanding of the chemistry of 2-acylazirines.
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European journal of organic chemistry, 2019, 42, Wiley-VCH, Weinheim, 2019, https://doi.org/10.1002/ejoc.201901176