Gutenberg Open Science: The physiological basis for contrast opponency in motion computation in Drosophila

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7001

Full metadata record

DC Field	Value	Language
dc.contributor.author	Ramos-Traslosheros, Giordano	-
dc.contributor.author	Silies, Marion	-
dc.date.accessioned	2022-05-19T09:18:05Z	-
dc.date.available	2022-05-19T09:18:05Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7013	-
dc.description.abstract	In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	The physiological basis for contrast opponency in motion computation in Drosophila	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7001	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Nature Communications	de
jgu.journal.volume	12	de
jgu.pages.alternative	4987	de
jgu.publisher.year	2021	-
jgu.publisher.name	Nature Publishing Group UK	de
jgu.publisher.place	London	de
jgu.publisher.issn	2041-1723	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.publisher.doi	10.1038/s41467-021-24986-w	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

Files in This Item:

	File	Description	Size	Format
	the_physiological_basis_for_c-20220519111535060.pdf		3.95 MB	Adobe PDF	View/Open

Show simple item record