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Authors: Ramos-Traslosheros, Giordano
Silies, Marion
Title: The physiological basis for contrast opponency in motion computation in Drosophila
Online publication date: 19-May-2022
Year of first publication: 2021
Language: english
Abstract: In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.
DDC: 570 Biowissenschaften
570 Life sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 10 Biologie
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Nature Communications
Pages or article number: 4987
Publisher: Nature Publishing Group UK
Publisher place: London
Issue date: 2021
ISSN: 2041-1723
Publisher DOI: 10.1038/s41467-021-24986-w
Appears in collections:JGU-Publikationen

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