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http://doi.org/10.25358/openscience-6986Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dietz, Sabrina | - |
| dc.contributor.author | Vasconcelos Almeida, Miguel | - |
| dc.contributor.author | Nischwitz, Emily | - |
| dc.contributor.author | Schreier, Jan | - |
| dc.contributor.author | Viceconte, Nikenza | - |
| dc.contributor.author | Fradera-Sola, Albert | - |
| dc.contributor.author | Renz, Christian | - |
| dc.contributor.author | Ceron-Noriega, Alejandro | - |
| dc.contributor.author | Ulrich, Helle D. | - |
| dc.contributor.author | Kappei, Dennis | - |
| dc.contributor.author | Ketting, René F. | - |
| dc.contributor.author | Butter, Falk | - |
| dc.date.accessioned | 2022-05-17T09:32:28Z | - |
| dc.date.available | 2022-05-17T09:32:28Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/6998 | - |
| dc.description.abstract | Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the telomere sequence is lacking. Here, we harnessed a quantitative proteomics approach to identify TEBP-1 and TEBP-2, two paralogs expressed in the germline and embryogenesis that associate to telomeres in vitro and in vivo. tebp-1 and tebp-2 mutants display strikingly distinct phenotypes: tebp-1 mutants have longer telomeres than wild-type animals, while tebp-2 mutants display shorter telomeres and a Mortal Germline. Notably, tebp-1;tebp-2 double mutant animals have synthetic sterility, with germlines showing signs of severe mitotic and meiotic arrest. Furthermore, we show that POT-1 forms a telomeric complex with TEBP-1 and TEBP-2, which bridges TEBP-1/-2 with POT-2/MRT-1. These results provide insights into the composition and organization of a telomeric protein complex in C. elegans. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 570 Biowissenschaften | de_DE |
| dc.subject.ddc | 570 Life sciences | en_GB |
| dc.title | The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1 | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-6986 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | Sonderforschungsbereiche (SFB) | de |
| jgu.organisation.number | 8570 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Nature Communications | de |
| jgu.journal.volume | 12 | de |
| jgu.pages.alternative | 2668 | de |
| jgu.publisher.year | 2021 | - |
| jgu.publisher.name | Nature Publishing Group UK | de |
| jgu.publisher.place | London | de |
| jgu.publisher.issn | 2041-1723 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 570 | de |
| jgu.publisher.doi | 10.1038/s41467-021-22861-2 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | JGU-Publikationen | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | the_doublestranded_dnabinding-20220517111834474.pdf | 7.15 MB | Adobe PDF | View/Open |