Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6986
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dc.contributor.authorDietz, Sabrina-
dc.contributor.authorVasconcelos Almeida, Miguel-
dc.contributor.authorNischwitz, Emily-
dc.contributor.authorSchreier, Jan-
dc.contributor.authorViceconte, Nikenza-
dc.contributor.authorFradera-Sola, Albert-
dc.contributor.authorRenz, Christian-
dc.contributor.authorCeron-Noriega, Alejandro-
dc.contributor.authorUlrich, Helle D.-
dc.contributor.authorKappei, Dennis-
dc.contributor.authorKetting, René F.-
dc.contributor.authorButter, Falk-
dc.date.accessioned2022-05-17T09:32:28Z-
dc.date.available2022-05-17T09:32:28Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/6998-
dc.description.abstractTelomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the telomere sequence is lacking. Here, we harnessed a quantitative proteomics approach to identify TEBP-1 and TEBP-2, two paralogs expressed in the germline and embryogenesis that associate to telomeres in vitro and in vivo. tebp-1 and tebp-2 mutants display strikingly distinct phenotypes: tebp-1 mutants have longer telomeres than wild-type animals, while tebp-2 mutants display shorter telomeres and a Mortal Germline. Notably, tebp-1;tebp-2 double mutant animals have synthetic sterility, with germlines showing signs of severe mitotic and meiotic arrest. Furthermore, we show that POT-1 forms a telomeric complex with TEBP-1 and TEBP-2, which bridges TEBP-1/-2 with POT-2/MRT-1. These results provide insights into the composition and organization of a telomeric protein complex in C. elegans.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleThe double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1en_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-6986-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentSonderforschungsbereiche (SFB)de
jgu.organisation.number8570-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleNature Communicationsde
jgu.journal.volume12de
jgu.pages.alternative2668de
jgu.publisher.year2021-
jgu.publisher.nameNature Publishing Group UKde
jgu.publisher.placeLondonde
jgu.publisher.issn2041-1723de
jgu.organisation.placeMainz-
jgu.subject.ddccode570de
jgu.publisher.doi10.1038/s41467-021-22861-2de
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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