Gutenberg Open Science: Non-invasive haemoglobin measurement as an index test to detect pre-operative anaemia in elective surgery patients : a prospective study

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6910

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DC Field	Value	Language
dc.contributor.author	Wittenmeier, Eva	-
dc.contributor.author	Paumen, Yuri	-
dc.contributor.author	Mildenberger, Philipp	-
dc.contributor.author	Smetiprach, Julia	-
dc.contributor.author	Pirlich, Nina	-
dc.contributor.author	Griemert, Eva-Verena	-
dc.contributor.author	Kriege, Marc	-
dc.contributor.author	Engelhard, Kristin	-
dc.date.accessioned	2022-04-27T09:02:56Z	-
dc.date.available	2022-04-27T09:02:56Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6921	-
dc.description.abstract	Non-invasive haemoglobin measurement using absolute values lacks the precision to be the sole basis for the treatment of pre-operative anaemia. However, it can possibly serve as a screening test, indexing ‘anaemia’ with high sensitivity when values remain under prespecified cut-off values. Based on previous data, non-invasive haemoglobin cut-off values (146 g.l−1 for women and 152 g.l−1 for men) detect true anaemia with 99% sensitivity. An index test with these prespecified cut-off values was verified by prospective measurement of non-invasive and invasive haemoglobin pre-operatively in elective surgical patients. In 809 patients, this showed an estimated sensitivity (95%CI) of 98.9% (94.1–99.9%) in women and 96.4% (91.0–99.0%) in men. This saved invasive blood tests in 9% of female and 28% of male patients. In female patients, a lower non-invasive haemoglobin cut-off value (138 g.l−1) would save 28% of invasive blood tests with a sensitivity of 95%. The target 99% sensitivity would be reached by non-invasive haemoglobin cut-off values of 152 g.l−1 in female and 162 g.l−1 in male patients, saving 3% and 9% of invasive blood tests, respectively. Bias and limits of agreement between non-invasive and laboratory haemoglobin levels were 2 and − 25 to 28 g.l−1, respectively. Patient and measurement characteristics did not influence the agreement between non-invasive and laboratory haemoglobin levels. Although sensitivity was very high, the index test using prespecified cut-off values just failed to reach the target sensitivity to detect true anaemia. Nevertheless, with respect to blood-sparing effects, the use of the index test in men may be clinically useful, while an index test with a lower cut-off (132 g.l−1) could be more clinically appropriate in women.	de_DE
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Non-invasive haemoglobin measurement as an index test to detect pre-operative anaemia in elective surgery patients : a prospective study	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6910	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Anaesthesia	de
jgu.journal.volume	76	de
jgu.journal.issue	5	de
jgu.pages.start	647	de
jgu.pages.end	654	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford u.a	de
jgu.publisher.issn	1365-2044	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/anae.15312	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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