Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6910
Authors: | Wittenmeier, Eva Paumen, Yuri Mildenberger, Philipp Smetiprach, Julia Pirlich, Nina Griemert, Eva-Verena Kriege, Marc Engelhard, Kristin |
Title: | Non-invasive haemoglobin measurement as an index test to detect pre-operative anaemia in elective surgery patients : a prospective study |
Online publication date: | 27-Apr-2022 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Non-invasive haemoglobin measurement using absolute values lacks the precision to be the sole basis for the treatment of pre-operative anaemia. However, it can possibly serve as a screening test, indexing ‘anaemia’ with high sensitivity when values remain under prespecified cut-off values. Based on previous data, non-invasive haemoglobin cut-off values (146 g.l−1 for women and 152 g.l−1 for men) detect true anaemia with 99% sensitivity. An index test with these prespecified cut-off values was verified by prospective measurement of non-invasive and invasive haemoglobin pre-operatively in elective surgical patients. In 809 patients, this showed an estimated sensitivity (95%CI) of 98.9% (94.1–99.9%) in women and 96.4% (91.0–99.0%) in men. This saved invasive blood tests in 9% of female and 28% of male patients. In female patients, a lower non-invasive haemoglobin cut-off value (138 g.l−1) would save 28% of invasive blood tests with a sensitivity of 95%. The target 99% sensitivity would be reached by non-invasive haemoglobin cut-off values of 152 g.l−1 in female and 162 g.l−1 in male patients, saving 3% and 9% of invasive blood tests, respectively. Bias and limits of agreement between non-invasive and laboratory haemoglobin levels were 2 and − 25 to 28 g.l−1, respectively. Patient and measurement characteristics did not influence the agreement between non-invasive and laboratory haemoglobin levels. Although sensitivity was very high, the index test using prespecified cut-off values just failed to reach the target sensitivity to detect true anaemia. Nevertheless, with respect to blood-sparing effects, the use of the index test in men may be clinically useful, while an index test with a lower cut-off (132 g.l−1) could be more clinically appropriate in women. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6910 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC |
Information on rights of use: | https://creativecommons.org/licenses/by-nc/4.0/ |
Journal: | Anaesthesia 76 5 |
Pages or article number: | 647 654 |
Publisher: | Wiley-Blackwell |
Publisher place: | Oxford u.a |
Issue date: | 2021 |
ISSN: | 1365-2044 |
Publisher DOI: | 10.1111/anae.15312 |
Appears in collections: | JGU-Publikationen |
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File | Description | Size | Format | ||
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![]() | noninvasive_haemoglobin_measu-20220427105610810.pdf | 378.76 kB | Adobe PDF | View/Open |