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Authors: Schuster, Alexander K.
Fischer, Joachim Ernst
Vossmerbäumer, Urs
Title: Central corneal thickness in spectral-domain OCT and associations with ocular and systemic parameters
Online publication date: 21-Jul-2016
Year of first publication: 2016
Language: english
Abstract: Background. Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods. A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations' model. Results. CCT measurements showed a significant association with corneal curvature and intraocular pressure: a thinner CCT was associated with a flatter cornea and with lower intraocular pressure (p < 0.001). Age was positively associated with CCT (p < 0.001); all other cardiovascular parameters were not associated. Conclusion. A thinner cornea is associated with a flatter surface and with lower intraocular pressure readings, while there are no independent associations with refraction and systemic cardiovascular parameters. Our findings highlight the value of SD-OCT CCT measurements as a standard tool in anterior segment analysis.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
URN: urn:nbn:de:hebis:77-publ-544032
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Journal of Ophthalmology
Pages or article number: Art. 2596956
Publisher: Hindawi
Publisher place: New York, NY
Issue date: 2016
ISSN: 2090-004X
Publisher URL:
Publisher DOI: 10.1155/2016/2596956
Appears in collections:JGU-Publikationen

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