Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://doi.org/10.25358/openscience-6727| Autoren: | Rosch, Moritz Lucas, Kurt Al-Gousous, Jozef Pöschl, Ulrich Langguth, Peter |
| Titel: | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| Online-Publikationsdatum: | 27-Jan-2022 |
| Erscheinungsdatum: | 2021 |
| Sprache des Dokuments: | Englisch |
| Zusammenfassung/Abstract: | Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations. |
| DDC-Sachgruppe: | 540 Chemie 540 Chemistry and allied sciences 610 Medizin 610 Medical sciences |
| Veröffentlichende Institution: | Johannes Gutenberg-Universität Mainz |
| Organisationseinheit: | FB 09 Chemie, Pharmazie u. Geowissensch. |
| Veröffentlichungsort: | Mainz |
| ROR: | https://ror.org/023b0x485 |
| DOI: | http://doi.org/10.25358/openscience-6727 |
| Version: | Published version |
| Publikationstyp: | Zeitschriftenaufsatz |
| Weitere Angaben zur Dokumentart: | Scientific article |
| Nutzungsrechte: | CC BY |
| Informationen zu den Nutzungsrechten: | https://creativecommons.org/licenses/by/4.0/ |
| Zeitschrift: | Pharmaceuticals 14 12 |
| Seitenzahl oder Artikelnummer: | 1327 |
| Verlag: | MDPI |
| Verlagsort: | Basel |
| Erscheinungsdatum: | 2021 |
| ISSN: | 1424-8247 |
| URL der Originalveröffentlichung: | https://doi.org/10.3390/ph14121327 |
| DOI der Originalveröffentlichung: | 10.3390/ph14121327 |
| Enthalten in den Sammlungen: | JGU-Publikationen |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | ||
|---|---|---|---|---|---|
 | formulation_and_characterizat-20220127094614246.pdf | 3.13 MB | Adobe PDF | Öffnen/Anzeigen |