Gutenberg Open Science: Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6727

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DC Field	Value	Language
dc.contributor.author	Rosch, Moritz	-
dc.contributor.author	Lucas, Kurt	-
dc.contributor.author	Al-Gousous, Jozef	-
dc.contributor.author	Pöschl, Ulrich	-
dc.contributor.author	Langguth, Peter	-
dc.date.accessioned	2022-01-27T09:13:18Z	-
dc.date.available	2022-01-27T09:13:18Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6738	-
dc.description.abstract	Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.	en_GB
dc.description.sponsorship	Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6727	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Pharmaceuticals	de
jgu.journal.volume	14	de
jgu.journal.issue	12	de
jgu.pages.alternative	1327	de
jgu.publisher.year	2021	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/ph14121327	de
jgu.publisher.issn	1424-8247	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/ph14121327	-
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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