Authors:	Rosch, Moritz Lucas, Kurt Al-Gousous, Jozef Pöschl, Ulrich Langguth, Peter
Title:	Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet
Online publication date:	27-Jan-2022
Year of first publication:	2021
Language:	english
Abstract:	Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.
DDC:	540 Chemie 540 Chemistry and allied sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6727
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Pharmaceuticals 14 12
Pages or article number:	1327
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2021
ISSN:	1424-8247
Publisher URL:	https://doi.org/10.3390/ph14121327
Publisher DOI:	10.3390/ph14121327
Appears in collections:	JGU-Publikationen