Authors:	Geske, Leander Kauhl, Ulrich Saaed, Mohamed E. M. Schüffler, Anja Thines, Eckhard Efferth, Thomas Opatz, Till
Title:	Xylochemical synthesis and biological evaluation of shancigusin C and bletistrin G ‡
Online publication date:	15-Nov-2021
Year of first publication:	2021
Language:	english
Abstract:	The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.
DDC:	570 Biowissenschaften 570 Life sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6508
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Molecules 26 11
Pages or article number:	3224
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2021
ISSN:	1420-3049
Publisher URL:	https://doi.org/10.3390/molecules26113224
Publisher DOI:	10.3390/molecules26113224
Appears in collections:	JGU-Publikationen