Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6462
Authors: | Ruan, Yue Patzak, Andreas Pfeiffer, Norbert Gericke, Adrian |
Title: | Muscarinic acetylcholine receptors in the retina: therapeutic implications |
Online publication date: | 9-Nov-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Muscarinic acetylcholine receptors (mAChRs) belong to the superfamily of G-protein-coupled receptors (GPCRs). The family of mAChRs is composed of five subtypes, M1, M2, M3, M4 and M5, which have distinct expression patterns and functions. In the eye and its adnexa, mAChRs are widely expressed and exert multiple functions, such as modulation of tear secretion, regulation of pupil size, modulation of intraocular pressure, participation in cell-to-cell signaling and modula-tion of vascular diameter in the retina. Due to this variety of functions, it is reasonable to assume that abnormalities in mAChR signaling may contribute to the development of various ocular diseases. On the other hand, mAChRs may offer an attractive therapeutic target to treat ocular diseases. Thus far, non-subtype-selective mAChR ligands have been used in ophthalmology to treat dry eye disease, myopia and glaucoma. However, these drugs were shown to cause various side-effects. Thus, the use of subtype-selective ligands would be useful to circumvent this problem. In this review, we give an overview on the localization and on the functional role of mAChR subtypes in the eye and its adnexa with a special focus on the retina. Moreover, we describe the pathophysiological role of mAChRs in retinal diseases and discuss potential therapeutic approaches. |
DDC: | 540 Chemie 540 Chemistry and allied sciences 570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6462 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Scientific article |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | International journal of molecular sciences 22 9 |
Pages or article number: | 4989 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2021 |
ISSN: | 1422-0067 1661-6596 |
Publisher URL: | https://doi.org/10.3390/ijms22094989 |
Publisher DOI: | 10.3390/ijms22094989 |
Appears in collections: | JGU-Publikationen |
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File | Description | Size | Format | ||
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ruan_yue-muscarinic_ace-20211105151029754.pdf | 755.73 kB | Adobe PDF | View/Open |