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Authors: Rauhala, Onni J.
Dominguez, Soledad
Spyropoulos, George D.
Ferrero, Jose Javier
Boyers, Talia R.
Jastrzebska-Perfect, Patricia
Cea, Claudia
Khodagholy, Dion
Gelinas, Jennifer N.
Title: Chitosan-based, biocompatible, solution processable films for in vivo localization of neural interface devices
Online publication date: 25-Oct-2021
Year of first publication: 2020
Language: english
Abstract: Chitosan (CS) is a biocompatible, inexpensive organic polymer that is increasingly used in neural tissue applications. However, its intrinsic fluorescence has not yet been leveraged to facilitate localization of neural interface devices, a key procedure to ensure accurate analysis of neurophysiological signals. A process is developed to enable control of mechanical and chemical properties of CS-based composites, generating freestanding films that are stable in aqueous environments and exhibit concentration-dependent fluorescence intensity. The shape and location of CS-coated probes are reliably visualized in vitro and in vivo using fluorescence microscopy. Furthermore, CS neural probe marking is fully compatible with classical immunohistochemical and histological techniques, enabling localization of high spatiotemporal resolution surface electrocorticography arrays in adult rats and mouse pups. CS composites have the potential to simplify and streamline experimental procedures required to efficiently acquire, localize, and interpret neurophysiological data.
DDC: 570 Biowissenschaften
570 Life sciences
600 Technik
600 Technology (Applied sciences)
610 Medizin
610 Medical sciences
620 Ingenieurwissenschaften und Maschinenbau
620 Engineering and allied operations
621.3 Elektrotechnik
621.3 Electric engineering
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY-NC
Information on rights of use:
Journal: Advanced materials technologies
Pages or article number: 1900663
Publisher: Wiley
Publisher place: Weinheim
Issue date: 2020
ISSN: 2365-709X
Publisher URL:
Publisher DOI: 10.1002/admt.201900663
Appears in collections:JGU-Publikationen

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