Autoren:	Li, Huige Kilgallen, Aoife B. Münzel, Thomas Wolf, Eva Lecour, Sandrine Schulz, Rainer Daiber, Andreas Laake, Linda W. Van
Titel:	Influence of mental stress and environmental toxins on circadian clocks : implications for redox regulation of the heart and cardioprotection
Online-Publikationsdatum:	24-Aug-2021
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Risk factors in the environment such as air pollution and mental stress contribute to the development of chronic non-communicable disease. Air pollution was identified as the leading health risk factor in the physical environment, followed by water pollution, soil pollution/heavy metals/chemicals and occupational exposures, however neglecting the non-chemical environmental health risk factors (e.g. mental stress and noise). Epidemiological data suggest that environmental risk factors are associated with higher risk for cardiovascular, metabolic and mental diseases, including hypertension, heart failure, myocardial infarction, diabetes, arrhythmia, stroke, depression and anxiety disorders. We provide an overview on the impact of the external exposome comprising risk factors/exposures on cardiovascular health with a focus on dysregulation of stress hormones, mitochondrial function, redox balance and inflammation with special emphasis on the circadian clock. Finally, we assess the impact of circadian clock dysregulation on cardiovascular health and the potential of environment-specific preventive strategies or “chrono” therapy for cardioprotection.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6302
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	British journal of pharmacology 177 23
Seitenzahl oder Artikelnummer:	5393 5412
Verlag:	Wiley
Verlagsort:	Malden, MA
Erscheinungsdatum:	2020
ISSN:	1476-5381
URL der Originalveröffentlichung:	https://doi.org/10.1111/bph.14949
DOI der Originalveröffentlichung:	10.1111/bph.14949
Enthalten in den Sammlungen:	JGU-Publikationen