Authors:	Li, Huige Kilgallen, Aoife B. Münzel, Thomas Wolf, Eva Lecour, Sandrine Schulz, Rainer Daiber, Andreas Laake, Linda W. Van
Title:	Influence of mental stress and environmental toxins on circadian clocks : implications for redox regulation of the heart and cardioprotection
Online publication date:	24-Aug-2021
Year of first publication:	2020
Language:	english
Abstract:	Risk factors in the environment such as air pollution and mental stress contribute to the development of chronic non-communicable disease. Air pollution was identified as the leading health risk factor in the physical environment, followed by water pollution, soil pollution/heavy metals/chemicals and occupational exposures, however neglecting the non-chemical environmental health risk factors (e.g. mental stress and noise). Epidemiological data suggest that environmental risk factors are associated with higher risk for cardiovascular, metabolic and mental diseases, including hypertension, heart failure, myocardial infarction, diabetes, arrhythmia, stroke, depression and anxiety disorders. We provide an overview on the impact of the external exposome comprising risk factors/exposures on cardiovascular health with a focus on dysregulation of stress hormones, mitochondrial function, redox balance and inflammation with special emphasis on the circadian clock. Finally, we assess the impact of circadian clock dysregulation on cardiovascular health and the potential of environment-specific preventive strategies or “chrono” therapy for cardioprotection.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6302
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	British journal of pharmacology 177 23
Pages or article number:	5393 5412
Publisher:	Wiley
Publisher place:	Malden, MA
Issue date:	2020
ISSN:	1476-5381
Publisher URL:	https://doi.org/10.1111/bph.14949
Publisher DOI:	10.1111/bph.14949
Appears in collections:	JGU-Publikationen