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Authors: Ellwardt, Erik
Geber, Christian
Lotz, Johannes
Birklein, Frank
Title: Heterogeneous presentation of caspr2 antibody-associated peripheral neuropathy : a case series
Online publication date: 16-Aug-2021
Language: english
Abstract: Contactin-associated protein 2–like (caspr2) antibodies have been discovered recently. Since then a multitude of patients with caspr2 antibodies presenting with different neurological symptoms have been reported. Here, we describe three patients with caspr2 antibodies with different types of pain/no pain in combination with peripheral neuropathy. The first patient, a 33-year-old woman, presented with erythromelalgia-like pain and autonomic symptoms; the second patient, a 58-year-old man, with paresthesia and pain while walking together with signs of peripheral motor neuron hyperexcitability in combination with optic neuritis, and the third patient, a 74-year-old man, without any pain but with polyneuropathy and encephalopathy. These cases illustrate the spectrum of symptoms in anti-caspr2 diseases. The pain in such cases can be treated causally.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: European journal of pain
Pages or article number: 1411
Publisher: Wiley-Blackwell
Publisher place: Malden, Mass. u.a.
Issue date: 2020
ISSN: 1532-2149
Publisher URL:
Publisher DOI: 10.1002/ejp.1572
Appears in collections:JGU-Publikationen

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