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http://doi.org/10.25358/openscience-6284Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wölfinger, Pascal | - |
| dc.contributor.author | Epp, Katharina | - |
| dc.contributor.author | Schaefer, Lukas | - |
| dc.contributor.author | Kriege, Diana | - |
| dc.contributor.author | Theobald, Matthias | - |
| dc.contributor.author | Bopp, Tobias | - |
| dc.contributor.author | Wagner-Drouet, Eva-Maria | - |
| dc.date.accessioned | 2021-08-16T08:56:45Z | - |
| dc.date.available | 2021-08-16T08:56:45Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/6294 | - |
| dc.description.abstract | Allogeneic haematopoietic stem cell transplantation (HSCT) after a reduced-intensity conditioning (RIC) regimen with fludarabine, melphalan and alemtuzmab is an effective therapy for haematological malignancies. Alemtuzumab, a monoclonal antibody against CD52, a glycosylphosphatidylinositol-anchor-bound surface protein on lymphocytes, depletes T cells to prevent graft-versus-host disease (GVHD). Despite this, acute and chronic GVHD (a/cGVHD) remain life-threatening complications after HSCT. The aim of the present study was to identify parameters to predict GVHD. In 69 patients after HSCT, T-cell subsets were functionally analysed. Reconstitution of CD52neg T cells and CD52neg regulatory T cells (Tregs) correlated with onset, severity and clinical course of aGVHD. Patients with aGVHD showed significantly lower levels of CD52pos T cells compared to patients with cGVHD or without GVHD (P < 0·001). Analysis of T-cell reconstitution revealed a percentage of <40% of CD52posCD4pos T cells or CD52pos Tregs at day +50 as a risk factor for the development of aGVHD. In contrast, CD52neg Tregs showed significant decreased levels of glycoprotein A repetitions predominant (GARP; P < 0·001), glucocorticoid-induced TNFR-related protein (GITR; P < 0·001), chemokine receptor (CXCR3; P = 0·023), C-C chemokine receptor type 5 (CCR5; P = 0·004), but increased levels of immunoglobulin-like transcript 3 (ILT3; P = 0·001), as well as a reduced suppressive capacity. We conclude that reconstitution of CD52neg T cells and CD52neg Tregs is a risk factor for development of aGVHD. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY-NC | * |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-6284 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | British journal of haematology | de |
| jgu.journal.volume | 191 | de |
| jgu.journal.issue | 2 | de |
| jgu.pages.start | 253 | de |
| jgu.pages.end | 262 | de |
| jgu.publisher.year | 2020 | - |
| jgu.publisher.name | Wiley-Blackwell | de |
| jgu.publisher.place | Oxford u.a. | de |
| jgu.publisher.uri | https://doi.org/10.1111/bjh.16706 | de |
| jgu.publisher.issn | 1365-2141 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1111/bjh.16706 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | woelfinger_pascal-cd52-negative_-20210816104941103.pdf | 1.22 MB | Adobe PDF | View/Open |