Authors:	Liebl, Magdalena C. Hofmann, Thomas G.
Title:	Cell fate regulation upon DNA damage : p53 Serine 46 kinases pave the cell death road
Online publication date:	13-Aug-2021
Year of first publication:	2019
Language:	english
Abstract:	Mild and massive DNA damage are differentially integrated into the cellular signaling networks and, in consequence, provoke different cell fate decisions. After mild damage, the tumor suppressor p53 directs the cellular response to cell cycle arrest, DNA repair, and cell survival, whereas upon severe damage, p53 drives the cell death response. One posttranslational modification of p53, phosphorylation at Serine 46, selectively occurs after severe DNA damage and is envisioned as a marker of the cell death response. However, the molecular mechanism of action of the p53 Ser46 phospho-isomer, the molecular timing of this phosphorylation event, and its activating effects on apoptosis and ferroptosis still await exploration. In this essay, the current body of evidence on the molecular function of this deadly p53 mark, its evolutionary conservation, and the regulation of the key players of this response, the p53 Serine 46 kinases, are reviewed and dissected.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6277
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Bioessays 41 12
Pages or article number:	1900127
Publisher:	Wiley-Liss
Publisher place:	New York, NY
Issue date:	2019
ISSN:	1521-1878
Publisher URL:	https://doi.org/10.1002/bies.201900127
Publisher DOI:	10.1002/bies.201900127
Appears in collections:	JGU-Publikationen