Autoren:	Ewald, Johannes Blankenburg, Jan Worm, Matthias Besch, Laura Unger, Ronald E. Tremel, Wolfgang Frey, Holger Pohlit, Hannah
Titel:	Acid-cleavable poly(ethylene glycol) hydrogels displaying protein release at pH 5
Online-Publikationsdatum:	3-Aug-2021
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring-opening copolymerization of ethylene oxide with 3,4-epoxy-1-butene (EPB) and subsequent modification to introduce acid-degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross-linking. Copolymers with different molar ratios of EPB, molecular weights (Mn) up to 10 000 g mol−1 and narrow dispersities (Đ<1.05) were prepared. Both the P(EG-co-isoEPB)MA copolymer and the hydrogels showed pH-dependent, rapid hydrolysis at pH 5–6 and long-term storage stability at neutral pH (pH 7.4). By designing the degree of polymerization and content of degradable vinyl ether groups, the release time of an entrapped protein OVA-Alexa488 can be tailored from a few hours to several days (hydrolysis half-life time t1/2 at pH 5: 13 h to 51 h).
DDC-Sachgruppe:	540 Chemie 540 Chemistry and allied sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 09 Chemie, Pharmazie u. Geowissensch.
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6236
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY-NC
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by-nc/4.0/
Zeitschrift:	Chemistry - a European journal 26 13
Seitenzahl oder Artikelnummer:	2947 2953
Verlag:	Wiley-VCH
Verlagsort:	Weinheim
Erscheinungsdatum:	2020
ISSN:	1521-3765
URL der Originalveröffentlichung:	https://doi.org/10.1002/chem.201905310
DOI der Originalveröffentlichung:	10.1002/chem.201905310
Enthalten in den Sammlungen:	JGU-Publikationen