Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6236
Authors: | Ewald, Johannes Blankenburg, Jan Worm, Matthias Besch, Laura Unger, Ronald E. Tremel, Wolfgang Frey, Holger Pohlit, Hannah |
Title: | Acid-cleavable poly(ethylene glycol) hydrogels displaying protein release at pH 5 |
Online publication date: | 3-Aug-2021 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring-opening copolymerization of ethylene oxide with 3,4-epoxy-1-butene (EPB) and subsequent modification to introduce acid-degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross-linking. Copolymers with different molar ratios of EPB, molecular weights (Mn) up to 10 000 g mol−1 and narrow dispersities (Đ<1.05) were prepared. Both the P(EG-co-isoEPB)MA copolymer and the hydrogels showed pH-dependent, rapid hydrolysis at pH 5–6 and long-term storage stability at neutral pH (pH 7.4). By designing the degree of polymerization and content of degradable vinyl ether groups, the release time of an entrapped protein OVA-Alexa488 can be tailored from a few hours to several days (hydrolysis half-life time t1/2 at pH 5: 13 h to 51 h). |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6236 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC |
Information on rights of use: | https://creativecommons.org/licenses/by-nc/4.0/ |
Journal: | Chemistry - a European journal 26 13 |
Pages or article number: | 2947 2953 |
Publisher: | Wiley-VCH |
Publisher place: | Weinheim |
Issue date: | 2020 |
ISSN: | 1521-3765 |
Publisher URL: | https://doi.org/10.1002/chem.201905310 |
Publisher DOI: | 10.1002/chem.201905310 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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ewald_johannes-acid-cleavable-20210802214519883.pdf | 1.05 MB | Adobe PDF | View/Open |