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Authors: Grundke, Caroline
Vierengel, Nina
Opatz, Till
Title: α-aminonitriles : from sustainable preparation to applications in natural product synthesis
Online publication date: 3-Aug-2021
Year of first publication: 2020
Language: english
Abstract: Due to their numerous reactivity modes, α-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on α-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders’ and Shilvock's seminal review. Natural α-aminonitriles will also briefly be treated.
DDC: 540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
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Journal: The chemical record
Pages or article number: 989
Publisher: Wiley
Publisher place: New York, NY u.a.
Issue date: 2020
ISSN: 1528-0691
Publisher URL:
Publisher DOI: 10.1002/tcr.202000066
Appears in collections:JGU-Publikationen

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