Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6229
Authors: | Grundke, Caroline Vierengel, Nina Opatz, Till |
Title: | α-aminonitriles : from sustainable preparation to applications in natural product synthesis |
Online publication date: | 3-Aug-2021 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | Due to their numerous reactivity modes, α-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on α-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders’ and Shilvock's seminal review. Natural α-aminonitriles will also briefly be treated. |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6229 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC-ND |
Information on rights of use: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Journal: | The chemical record 20 9 |
Pages or article number: | 989 1016 |
Publisher: | Wiley |
Publisher place: | New York, NY u.a. |
Issue date: | 2020 |
ISSN: | 1528-0691 |
Publisher URL: | https://doi.org/10.1002/tcr.202000066 |
Publisher DOI: | 10.1002/tcr.202000066 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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![]() | grundke_caroline-urn_x-wiley_15-20210802210139579.pdf | 19.08 MB | Adobe PDF | View/Open |