Authors:	Grundke, Caroline Vierengel, Nina Opatz, Till
Title:	α-aminonitriles : from sustainable preparation to applications in natural product synthesis
Online publication date:	3-Aug-2021
Year of first publication:	2020
Language:	english
Abstract:	Due to their numerous reactivity modes, α-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on α-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders’ and Shilvock's seminal review. Natural α-aminonitriles will also briefly be treated.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6229
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC-ND
Information on rights of use:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal:	The chemical record 20 9
Pages or article number:	989 1016
Publisher:	Wiley
Publisher place:	New York, NY u.a.
Issue date:	2020
ISSN:	1528-0691
Publisher URL:	https://doi.org/10.1002/tcr.202000066
Publisher DOI:	10.1002/tcr.202000066
Appears in collections:	JGU-Publikationen