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Authors: Geyer, Martin
Keller, Karsten
Born, Sonja
Bachmann, Kevin
Tamm, Alexander R.
Ruf, Tobias F.
Kreidel, Felix
Hahad, Omar
Ahoopai, Majid
Hobohm, Lukas
Beiras-Fernandez, Andres
Kornberger, Angela
Schulz, Eberhard
Münzel, Thomas
Bardeleben, Ralph Stephan von
Title: Predictors of short- and long-term outcomes of patients undergoing transcatheter mitral valve edge-to-edge repair
Online publication date: 2-Aug-2021
Year of first publication: 2021
Language: english
Abstract: OBJECTIVES Transcatheter mitral valve repair (TMVR) by edge-to-edge therapy is an established treatment for severe mitral valve regurgitation (MR). BACKGROUND Symptomatic and prognostic benefit in functional MR has been shown recently; nevertheless, data on long-term outcomes are sparse. METHODS AND RESULTS We analyzed survival of patients treated with isolated edge-to-edge repair from June 2010 to March 2018 (primarily combined edge-to-edge repair with other mitral valve interventions was excluded) in a retrospective monocentric study. Overall, 627 consecutive patients (47.0% females, 78.6 years in mean) were included. Leading etiology was functional MR (57.4%). Follow-up regarding survival was available in 97.0%. While 97.6% were discharged alive, 75.7% were alive after a 1-year, 54.5% after 3-year, 37.6% after 5-year and 21.7% after 7-year follow-up. Higher logistic Euroscores and comorbidities such as COPD and renal insufficiency were associated with higher in-hospital and 1-year mortality. Importantly, in-hospital survival increased over the years. CONCLUSIONS With the present study we established high survival rates at discharge and after 1 year of patients treated with TMVR. This goes along with high implantation numbers, increased interventional experience and a better in-hospital survival over the years. Long-term mortality in turn was substantially influenced by comorbidities.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
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Journal: Catheterization and cardiovascular interventions
Pages or article number: E390
Publisher: Wiley Interscience
Publisher place: New York, NY
Issue date: 2021
ISSN: 1522-726X
Publisher URL:
Publisher DOI: 10.1002/ccd.29068
Appears in collections:JGU-Publikationen

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