Authors:	Geyer, Martin Keller, Karsten Born, Sonja Bachmann, Kevin Tamm, Alexander R. Ruf, Tobias F. Kreidel, Felix Hahad, Omar Ahoopai, Majid Hobohm, Lukas Beiras-Fernandez, Andres Kornberger, Angela Schulz, Eberhard Münzel, Thomas Bardeleben, Ralph Stephan von
Title:	Predictors of short- and long-term outcomes of patients undergoing transcatheter mitral valve edge-to-edge repair
Online publication date:	2-Aug-2021
Year of first publication:	2021
Language:	english
Abstract:	OBJECTIVES Transcatheter mitral valve repair (TMVR) by edge-to-edge therapy is an established treatment for severe mitral valve regurgitation (MR). BACKGROUND Symptomatic and prognostic benefit in functional MR has been shown recently; nevertheless, data on long-term outcomes are sparse. METHODS AND RESULTS We analyzed survival of patients treated with isolated edge-to-edge repair from June 2010 to March 2018 (primarily combined edge-to-edge repair with other mitral valve interventions was excluded) in a retrospective monocentric study. Overall, 627 consecutive patients (47.0% females, 78.6 years in mean) were included. Leading etiology was functional MR (57.4%). Follow-up regarding survival was available in 97.0%. While 97.6% were discharged alive, 75.7% were alive after a 1-year, 54.5% after 3-year, 37.6% after 5-year and 21.7% after 7-year follow-up. Higher logistic Euroscores and comorbidities such as COPD and renal insufficiency were associated with higher in-hospital and 1-year mortality. Importantly, in-hospital survival increased over the years. CONCLUSIONS With the present study we established high survival rates at discharge and after 1 year of patients treated with TMVR. This goes along with high implantation numbers, increased interventional experience and a better in-hospital survival over the years. Long-term mortality in turn was substantially influenced by comorbidities.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6228
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Catheterization and cardiovascular interventions 97 3
Pages or article number:	E390 E401
Publisher:	Wiley Interscience
Publisher place:	New York, NY
Issue date:	2021
ISSN:	1522-726X
Publisher URL:	https://doi.org/10.1002/ccd.29068
Publisher DOI:	10.1002/ccd.29068
Appears in collections:	JGU-Publikationen