Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6213
Authors: | Michel, Maurice Kaps, Leonard Maderer, Annett Galle, Peter R. Moehler, Markus |
Title: | The role of p53 dysfunction in colorectal cancer and its implication for therapy |
Online publication date: | 2-Aug-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide. The carcinogenesis of CRC is based on a stepwise accumulation of mutations, leading either to an activation of oncogenes or a deactivation of suppressor genes. The loss of genetic stability triggers activation of proto-oncogenes (e.g., KRAS) and inactivation of tumor suppression genes, namely TP53 and APC, which together drive the transition from adenoma to adenocarcinoma. On the one hand, p53 mutations confer resistance to classical chemotherapy but, on the other hand, they open the door for immunotherapy, as p53-mutated tumors are rich in neoantigens. Aberrant function of the TP53 gene product, p53, also affects stromal and non-stromal cells in the tumor microenvironment. Cancer-associated fibroblasts together with other immunosuppressive cells become valuable assets for the tumor by p53-mediated tumor signaling. In this review, we address the manifold implications of p53 mutations in CRC regarding therapy, treatment response and personalized medicine. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6213 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Scientific article |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Cancers 13 10 |
Pages or article number: | 2296 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2021 |
ISSN: | 2072-6694 |
Publisher URL: | https://doi.org/10.3390/cancers13102296 |
Publisher DOI: | 10.3390/cancers13102296 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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michel_maurice-the_role_of_p5-20210723162504858.pdf | 1.13 MB | Adobe PDF | View/Open |