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Authors: Richtering, Walter
Alberg, Irina
Zentel, Rudolf
Title: Nanoparticles in the biological context : surface morphology and protein corona formation
Online publication date: 6-Jul-2021
Year of first publication: 2020
Language: english
Abstract: A recent paper demonstrated that the formation of a protein corona is not a general property of all types of nanosized objects. In fact, it varies between a massive aggregation of plasma proteins onto the nanoparticle down to traces (e.g., a few proteins per 10 nanoparticles), which can only be determined by mass spectrometry in comparison to appropriate negative controls and background subtraction. Here, differences between various types of nanosized objects are discussed in order to determine general structure–property-relations from a physico-chemical viewpoint. It is highlighted that “not all nanoparticles are alike” and shown that their internal morphology, especially the difference between a strongly hydrated/swollen shell versus a sharp “hard” surface and its accessibility, is most relevant for biomedical applications.
DDC: 540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
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Journal: Small
Pages or article number: 2002162
Publisher: Wiley-VCH
Publisher place: Weinheim
Issue date: 2020
ISSN: 1613-6829
Publisher URL:
Publisher DOI: 10.1002/smll.202002162
Appears in collections:JGU-Publikationen

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