Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6179
Authors: | Richtering, Walter Alberg, Irina Zentel, Rudolf |
Title: | Nanoparticles in the biological context : surface morphology and protein corona formation |
Online publication date: | 6-Jul-2021 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | A recent paper demonstrated that the formation of a protein corona is not a general property of all types of nanosized objects. In fact, it varies between a massive aggregation of plasma proteins onto the nanoparticle down to traces (e.g., a few proteins per 10 nanoparticles), which can only be determined by mass spectrometry in comparison to appropriate negative controls and background subtraction. Here, differences between various types of nanosized objects are discussed in order to determine general structure–property-relations from a physico-chemical viewpoint. It is highlighted that “not all nanoparticles are alike” and shown that their internal morphology, especially the difference between a strongly hydrated/swollen shell versus a sharp “hard” surface and its accessibility, is most relevant for biomedical applications. |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6179 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC |
Information on rights of use: | https://creativecommons.org/licenses/by-nc/4.0/ |
Journal: | Small 16 39 |
Pages or article number: | 2002162 |
Publisher: | Wiley-VCH |
Publisher place: | Weinheim |
Issue date: | 2020 |
ISSN: | 1613-6829 |
Publisher URL: | https://doi.org/10.1002/smll.202002162 |
Publisher DOI: | 10.1002/smll.202002162 |
Appears in collections: | JGU-Publikationen |
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File | Description | Size | Format | ||
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richtering_walter-nanoparticles_-20210705133333563.pdf | 678.01 kB | Adobe PDF | View/Open |