Authors:	Stoye, Nicolai M. Santos Guilherme, Malena dos Endres, Kristina
Title:	Alzheimer's disease in the gut : major changes in the gut of 5xFAD model mice with ApoA1 as potential key player
Online publication date:	5-Jul-2021
Year of first publication:	2020
Language:	english
Abstract:	Alzheimer's disease (AD) affects around 33 million people worldwide, which makes it the most prominent form of dementia. The main focus of AD research has been on the central nervous system (CNS) for long, but in recent years, the gut gained more attention. The intestinal tract is innervated by the enteric nervous system (ENS), built of numerous different types of neurons showing great similarity to neurons of the CNS. It already has been demonstrated that the amyloid precursor protein, which plays a major role in AD pathology, is also expressed in these cells. We analyzed gut tissue of AD model mice (5xFAD) and the respective wild-type littermates at different pathological stages: pre-pathological, early pathological and late pathological. Our results show significant difference in function of the intestine of 5xFAD mice as compared to wild-type mice. Using a pathway array detecting 84 AD-related gene products, we found ApoA1 expression significantly altered in colon tissue of 5xFAD mice. Furthermore, we unveil ApoA1's beneficial impact on cell viability and calcium homeostasis of cultured enteric neurons of 5xFAD animals. With this study, we demonstrate that the intestine is altered in AD-like pathology and that ApoA1 might be one key player within the gut.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6167
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	The FASEB journal 34 9
Pages or article number:	11883 11899
Publisher:	Wiley
Publisher place:	Hoboken, NJ
Issue date:	2020
ISSN:	1530-6860
Publisher URL:	https://doi.org/10.1096/fj.201903128RR
Publisher DOI:	10.1096/fj.201903128RR
Appears in collections:	JGU-Publikationen