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Authors: Ruan, Yue
Jiang, Subao
Gericke, Adrian
Title: Age-related macular degeneration : role of oxidative stress and blood vessels
Online publication date: 31-May-2021
Year of first publication: 2021
Language: english
Abstract: Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.
DDC: 570 Biowissenschaften
570 Life sciences
610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY
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Journal: International journal of molecular sciences
Pages or article number: 1296
Publisher: MDPI
Publisher place: Basel
Issue date: 2021
ISSN: 1422-0067
Publisher URL:
Publisher DOI: 10.3390/ijms22031296
Appears in collections:JGU-Publikationen

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