Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5922
Authors: | Man, Andy W. C. Li, Huige Xia, Ning |
Title: | Circadian rhythm: potential therapeutic target for atherosclerosis and thrombosis |
Online publication date: | 31-May-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock. |
DDC: | 570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5922 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Scientific article |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | International journal of molecular sciences 2 22 |
Pages or article number: | 676 |
Publisher: | Molecular Diversity Preservation International |
Publisher place: | Basel |
Issue date: | 2021 |
ISSN: | 1422-0067 1661-6596 |
Publisher URL: | https://doi.org/10.3390/ijms22020676 |
Publisher DOI: | 10.3390/ijms22020676 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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man_andy_w._c.-circadian_rhyt-20210514134248206.pdf | 1.35 MB | Adobe PDF | View/Open |