Authors:	Chmitorz, Andrea Neumann, Rebecca Johanna Kollmann, Bianca Ahrens, Kira Florence Öhlschläger, S. Goldbach, N. Weichert, D. Schick, Anita Lutz, B. Plichta, Michael M. Fiebach, C. J. Wessa, Michèle Kalisch, Raffael Tüscher, Oliver Lieb, K. Reif, Andreas
Title:	Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors : the longitudinal resilience assessment (LORA) study
Online publication date:	26-Aug-2021
Year of first publication:	2021
Language:	english
Abstract:	Resilience is the maintenance and/or quick recovery of mental health during and after periods of adversity. It is conceptualized to result from a dynamic process of successful adaptation to stressors. Up to now, a large number of resilience factors have been proposed, but the mechanisms underlying resilience are not yet understood. To shed light on the complex and time-varying processes of resilience that lead to a positive long-term outcome in the face of adversity, the Longitudinal Resilience Assessment (LORA) study has been established. In this study, 1191 healthy participants are followed up at 3- and 18-month intervals over a course of 4.5 years at two study centers in Germany. Baseline and 18-month visits entail multimodal phenotyping, including the assessment of mental health status, sociodemographic and lifestyle variables, resilience factors, life history, neuropsychological assessments (of proposed resilience mechanisms), and biomaterials (blood for genetic and epigenetic, stool for microbiome, and hair for cortisol analysis). At 3-monthly online assessments, subjects are monitored for subsequent exposure to stressors as well as mental health measures, which allows for a quantitative assessment of stressor-dependent changes in mental health as the main outcome. Descriptive analyses of mental health, number of stressors including major life events, daily hassles, perceived stress, and the ability to recover from stress are here presented for the baseline sample. The LORA study is unique in its design and will pave the way for a better understanding of resilience mechanisms in humans and for further development of interventions to successfully prevent stress-related disorder.
DDC:	150 Psychologie 150 Psychology 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5885
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	European archives of psychiatry and clinical neuroscience 271
Pages or article number:	1035 1051
Publisher:	Springer
Publisher place:	Berlin u.a.
Issue date:	2021
ISSN:	1433-8491
Publisher URL:	https://doi.org/10.1007/s00406-020-01159-2
Publisher DOI:	10.1007/s00406-020-01159-2
Appears in collections:	JGU-Publikationen