Authors:	Wild, Johannes Wenzel, Philip
Title:	Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension
Online publication date:	19-May-2021
Year of first publication:	2021
Language:	english
Abstract:	Although essential hypertension affects a large proportion of the human population and is one of the key drivers of cardiovascular mortality worldwide, we still do not have a complete understanding of its pathophysiology. More than 50 years ago, the immune system has been identified as an important part of the pathogenesis of arterial hypertension. An exceeding variety of recent publications deals with the interplay between the numerous different components of the immune system and mechanisms of arterial hypertension and has substantially contributed to our understanding of the role of immunity and inflammation in the pathogenesis of the disease. In this review, we focus on myeloid cells and anatomical barriers as particular aspects of innate immunity in arterial hypertension. Since it represents a first line of defense protecting against pathogens and maintaining tissue homeostasis, innate immunity provides many mechanistic hinge points in the area of hypertension.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5870
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Journal of molecular medicine 99
Pages or article number:	315 326
Publisher:	Springer
Publisher place:	Berlin u.a.
Issue date:	2021
ISSN:	1432-1440
Publisher URL:	https://doi.org/10.1007/s00109-020-02019-1
Publisher DOI:	10.1007/s00109-020-02019-1
Appears in collections:	JGU-Publikationen